- Gene set enrichment analysis revealed enhanced representation of MYC, FAS and mTOR pathways in HIV-DLBCL when compared to IC-DLBCL.- HIV-ABC showed enrichment of MYC and ARF pathways when compared to IC-ABC.- The authors identified 13 recurrent copy number losses and 16 recurrent copy number gains among B-cell derived AIDS-related lymphomas. Here, MTOR is linked to aneurysmal bone cyst.