BCL2 and diffuse large B-cell lymphoma: - Both HIV-DLBCL and IC-DLBCL groups were enriched in GCB subtype.- Increased frequency of Ki-67 >80% in HIV-DLBCL.- Reduced frequency of BCL2 positivity in HIV-DLBCL.- IC-DLBCL samples showed more copy number variations (CNVs) than HIV-DLBCL subjects.- 126 genes were differentially expressed between IC-DLBCL and HIV-DLBCL.- Gene set enrichment analysis indicated enhancement of genes associated with cell cycle progression, DNA replication and DNA repair in HIV-DLBCL.