- 2,523 genes found differentially expressed between HIV-DLBCL and IC-DLBCL applying an adjusted p -value of <0.1.- HIV status and DLBCL subtypes were not associated with OS differences.- IFNγ and IFNα were markers of positive prognostic among HIV-DLBCL only.- Ki-67 staining ≥80% was associated with lower survival among HIV-DLBCL.- cMYC/BCL2 co-expression was associated with lower survival independent of HIV status. Here, BCL2 is linked to diffuse large B-cell lymphoma.