Within the TFH population we further examined TFH1, TFH2 and TFH17 subset composition based on expression of chemokine receptors CXCR3 and CCR6 (24) and found that CLL patients demonstrate significant skewing towards the CXCR3+CCR6- TFH1 population (Figure 1C). This evidence concerns the gene CXCR3 and B-cell chronic lymphocytic leukemia.