It has been shown that VEGF weakens the antitumor immune response through two main modes of action: first, VEGF was shown to block the infiltration of T cells into the tumor by inhibiting the adhesion of lymphocytes to activated endothelial cells; and second, VEGF was shown to promote the function of immunomodulatory cells through a variety of mechanisms (72). This evidence concerns the gene VEGFA and neoplasm.