Hereof, many strategies have been brought forth to regulate the immune system in cancer patients which include immune checkpoint inhibitors targeting programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) pathway to reinstate an antitumor response, adoptive T cell therapy as well as cancer vaccines etc. Interestingly enough, there was an exhilarating connection between cancer immunotherapy and ferroptosis, as suggested by Wang W et al., and could be manipulated by CD8+ T cells (26). The gene discussed is CD8A; the disease is cancer.