Along with its role in the CCT protein folding complex promoting the folding of substrates like actin, we showed that CCT2 supports the proliferation of cancer cells in 2D and 3D conditions, correlates with the expression of oncogenes like MYC, and thus may fulfill the basic requirements for an oncogene as it undergoes genomic amplification during the mutational processes that drive tumorigenesis (56, 57). Here, MYC is linked to cancer.