ZEB2 and breast cancer: For example, in breast cancer, the GATA3/G9A/NuRD(MTA3) complex inhibited the expression of Zeb2 by catalyzing H3K9 methylation of ZEB2 promoter (23), while Snail suppressed the expression of E-cadherin by recruiting histone lysine-specific demethylase 1 (LSD1) to CDH1 promoter (24).