This effect is achieved by increasing apoptosis through the upregulation of apoptosis-related proteins (Bcl-xL and Caspase 8) and inhibition of cyclin D1, CDK4, and CDK6 expression, which arrested the cell cycle of EJ and UMUC3 bladder cancer cells in the G1/S phase (81). Here, CCND1 is linked to urinary bladder cancer.