Morin decreases CDK2, CDK4, cyclin D1, and cyclin E via modulation of the p21/WAF1 pathway, suppressing c-Jun N-terminal kinase (JNK) and AKT phosphorylation, and preventing MMP-9 expression by repressing NF-κB, SP-1, and AP-1 in EJ bladder cancer cells (29). Here, CDKN1A is linked to urinary bladder cancer.