In addition, it enhances p21/WAF1, p38, p53, p-ATM, p-BRCA1 DNA repair-associated, Bax, and BH3 interacting domain death agonist (Bid) expression, leading to S phase arrest and the induction of apoptosis of EJ bladder cancer cells (28). The gene discussed is CDKN1A; the disease is urinary bladder cancer.