As a traditional malignant tumor phenotype, the gene signature of the invasion group consisted of NHSL1, OCLN, EPB41L4B, PLAUR, PIK3CB, EPB41L5, ID4, TPM4, and MARVELD2. TPM4 showed the opposite effects in colon cancer and lung cancer. This evidence concerns the gene MARVELD2 and malignant colon neoplasm.