PVT1 and familial pancreatic carcinoma: Pvt1 oncogene (PVT1) is an lncRNA that is greater than 30 kb in size (90) and is upregulated in cancers (especially various cancers of the digestive system, including esophageal, gastric, primary liver, and pancreatic cancer and CRC) and can promote tumor cell proliferation, migration, and invasion (91).