MALAT1 can promote the growth and migration of CRC cells by competitively binding to the splicing factor proline- and glutamine-rich (SFPQ) tumor suppressor gene and releasing SFPQ from the SFPQ/polypyrimidine tract-binding protein 2 (PTBP2) complex, resulting in an increase in free proto-oncogene PTBP2, suggesting that MALAT1 can be a potential therapeutic target for CRC (81). The gene discussed is PTBP2; the disease is colorectal carcinoma.