Affected by cell density, YAP1 could act as a new determinant of iron ptosis, while by promoting cell resistance to apoptosis, YAP1 will greatly increase the sensitivity of cancer cells to iron death and may be resistant to YAP1 activated drug-resistant metastatic tumors, thus showing a therapeutic potential in cancers (38, 39). The gene discussed is YAP1; the disease is metastatic neoplasm.