In univariable analysis, B7-H3 expression in cancer cells and moderate-versus-poor tumor differentiation were significantly associated with better post-surgical ampullary cancer patient survival as well as disease-free survival (Hazard ratio’s <1), while higher T-stage, presence of lymph node metastases, and CA-19-9 levels above median values were associated with worse post-surgical outcomes (Hazard ratio’s >1) (Tables 3A, 4A). The gene discussed is CD276; the disease is metastatic malignant neoplasm in the lymph nodes.