UBB and hepatocellular carcinoma: Among all genetic aberrations identified, coding variants of TP53 (p.R43H, p.V25F, p.Y73S, p.M105I, p.R117S, p.P118L, p.I119F, and p.G134R), TTN (p.L13269S, p.R14571H, p.Y18131X, p.K23328T, p.L4170S, p.C4883G, and p.T13281fs), ADGRV1 (p.D1652V, p.T1691M, p.E4479X, and p.E4482V), CTNNB1 (p.S37A, p.D32G, p.S33P, and p.S33C), transmembrane protein 141 (TMEM141) (p.M1L), and ubiquitin B (UBB) (p.S65L) occurred in 38, 31, 27, 15, 12, and 12% of 26 individual samples, respectively, of patients with HCC (Supplementary Figure 6A).