RYR2 and hepatocellular carcinoma: Driver mutations in COL1A1 and GABBR1 were detected in 41 and 38% of HCC patients, respectively, and were the most commonly mutated genes, followed by TP53 (30%), RYR1 (22%), ATP2A3 (21%), IGF1R (20%), TPO (20%), CDH7 (18%), DCC (18%), HUWE1 (18%), RYR2 (18%), ANK3 (14%), CTNNB1 (14%), and DNAH3 (14%) (Figure 2B). Interestingly, frameshift deletion mutations in COL1A1 and GABBR1 were more commonly identified than missense mutations in other driver genes.