Cytosolic localization of LDHA was observed in malignant, CANT and normal brain, however, the percentage of cells showing nuclear LDHA was significantly higher in GBM compared to normal brain (35% vs. 2%, p = <0.001, Figures 4, 5, Table 3) with CANT samples showing a higher mean value than normal brain (27% vs. 2%, respectively, p = 0.062, Figures 4, 5, Table 3). This evidence concerns the gene LDHA and glioblastoma.