NAFLD: non-alcoholic fatty liver disease; DKK-1: Dickkopf-related protein-1; RANKL: receptor activator of nuclear factor κβ ligand; PICP: carboxy-terminal propeptide of type I procollagen; PINP: amino-terminal propeptide of type I procollagen; ALP: total alkaline phosphatase; ICTP: telopeptide of type I collagen; TRAP: tartrate-resistant acid phosphatase; HYP: hydroxyproline; PYR: pyridinoline; DPYR: deoxypyridinoline; NTX: type I collagen cross-linked N; CTX: C-telopeptide; UDPD: urinary deoxypyridinoline. Here, PHEX is linked to metabolic dysfunction-associated steatotic liver disease.