Although the disease onset was earlier in mutated cases as compared to un-mutated cases, and mutants had a relatively severe type of pancreatitis, clinical severity, and structural abnormality cannot be decided solely on the basis of this targeted genetic defect of the SPINK1 gene; rather, there might be some other hidden factors, a variable role of the environment, and other associated, unknown genetic mutations, which might have a contributory role in the phenotypical and morphological presentations of the disease, which needs to be meticulously addressed in future studies. Here, SPINK1 is linked to pancreatitis.