Although the TCF7L2 encodes the main effector involved in this signaling pathway, few studies investigate the association between the rs7903146 and risk for obesity (Haupt et al., 2010; Al-Daghri et al., 2014; Locke et al., 2015; Abadi et al., 2017; Muller et al., 2019). Here, TCF7L2 is linked to obesity due to melanocortin 4 receptor deficiency.