CD4 and neoplasm: We can notice that the relative infiltrating levels of B cells (Cor = 0.428, P = 3.254e−21) and CD4+ T cells (Cor = 0.484, P = 1.705e−27) have strong correlation with risk score (Figs. 7A–7F), which meant that immune-related genes in the signature might influence the tumor immune microenvironment by promoting B cells and CD4+ T cells to infiltrate into the tumor tissue.