We filtered 12 immune-related genes (CD1B, LTB4R, IL13, PLCG2, BDNF, DKK1, GRP, IGF1, SPP1, UCN, UTS2 and FAS) with prognostic value for colon cancer and used them to construct an immune-related signature. The gene discussed is GRP; the disease is malignant colon neoplasm.