CST3 and liver dysplastic nodule: Many markers such as cystatin C, alpha 1-microglobulin, immunoglobulin G or M, angiotensinogen, liver-type fatty acid-binding protein, urinary transferrin, serum osteopontin, urinary retinol-binding protein, and interleukin-18 have been screened as early indicators of DN [6, 9–13].