Hetherington et al. prepared and investigated a series of constrained peptides to target HIF-1α/p300;46 a PPI which regulates oxygen levels in cells and is often hijacked by cancer to supply growing tumours with oxygen.47–49 Here, the peptides were constrained through reaction of dibromomaleimide with i and i + 4 Cys residues.21,50 One of the dibromomaleimide (DBM) stapled HIF-1α peptides demonstrated a significant enhancement of binding affinity for p300 in comparison to the unconstrained native peptide. Here, EP300 is linked to cancer.