As shown in Table 1, the degree of pancreatic injury in patients with severe acute pancreatitis gradually aggravated with the extension of modeling time; drug can effectively improve the early condition of sap; with the progress of the disease, the expression of CARD9 mRNA and phosphorylated CARD9 protein in pancreatic tissue also increased; the expression and phosphorylation of CARD9 mRNA in pancreatic tissue of patients with severe acute pancreatitis in cqcqd group CARD9 protein was significantly lower than that of SAP group at the same time point. Here, CARD9 is linked to acute pancreatitis.