HMGCR and familial hypercholesterolemia: However, since lipid-lowering abilities of A. Graveolens L. extract and dill tablets through down-regulation of HMG-CoA reductase gene and inhibition of its activity were observed in our previous study (10), we hypothesized that dill tablets may exhibit a beneficial effect on the HCD-induced AD model by lowering serum cholesterol and attenuating unpleasant aspects of hypercholesterolemia, including alleviation of Aβ deposits and enhancing learning and memory abilities.