The search keywords included metabolic syndrome, hypertension, blood pressure, hypotensive, antihypertensive, dyslipidemia, hyperlipidemia, high cholesterol, high triglyceride, hypercholesterolemia, hypertriglyceridemia, atherogenic, atherosclerosis, obesity, overweight, appetite, anti-obesity, weight loss, diabetes, hyperglycemia, insulin, hypoglycemic, antihyperglycemic, antidiabetic, blood glucose, neem, and Azadirachta indica. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.