However, there were debilitating impacts of HIV on the HAART naïve volunteers leading to HIV induced loss of immunity as a result of extremely high HIV RNA viral load - a proxy for the average transmission risk in a given population [20] as well as decrease in CD4 count, malnutrition and opportunistic infections with loss of weight (Table 1) as one of the significant consequences [21]. Here, CD4 is linked to Opportunistic infection.