More importantly, TGFBR2 knockdown (Figure S3C) inhibited the stemness of both A549-Teton-shMYOCD to a similar degree as LY2109761 did in SFA in vitro (Figure 3D & S3B) and tumor formation assays in vivo (Figure 3E). The gene discussed is TGFBR2; the disease is neoplasm.