Longitudinal PET imaging study on 5xFAD mice and its age-matched WT littermates, with the same genetic background, using carbon-11 radiolabelled [11C]4, revealed that the trend of longitudinal increase of BChE levels in the brain between AD and control mice correspond to Aβ deposition rate from 4 to 8 months of age. This evidence concerns the gene BCHE and Alzheimer disease.