BCHE and Alzheimer disease: The tracer proved efficient in quantifying cerebral BChE enzymatic activity and distinguished AD from healthy, age-matched mouse brains, showing 1.5- and 2.0-fold differences (AD vs. wild type, WT) at 60 min post injection for the hippocampus and cerebral cortex, respectively, at the age of 11.1 ± 1.1 months.