Pathophysiologically, AD is characterized by the accumulation of amyloid-β (Aβ) aggregates in various conformations 5, the appearance of filamentous intraneuronal inclusions, dystrophic neurites and neurophilic threads whose main constituent is hyperphosphorylated Tau protein (p-Tau) 6, and synaptic dysfunction 7. This evidence concerns the gene MAPT and Alzheimer disease.