Furthermore, the gene set enrichment analysis (GSEA) plots for SIRT6 in TCGA (PanCancer Atlas) also revealed that high expression of prostate cancer-related genes and activation of the cancer-related pathways were accompanied with the elevated expression of SIRT6 (Figure 1C), indicating that SIRT6 might have a positive effect on prostate cancer progression. This evidence concerns the gene SIRT6 and Familial prostate cancer.