The GSEA in Metastatic Prostate Cancer (SU2C/PCF Dream Team, Cell 2015) dataset from cBioportal found that histone deacetylation was enriched in the SIRT6 high expression group, indicating histone deacetylation may be associated with the malignancy development driven by SIRT6 (Figure S5A). This evidence concerns the gene SIRT6 and Familial prostate cancer.