TMIT I (high PD-L1 and CD8A) represent inflamed tumor that might respond favorably to ICIs, TMIT II (low PD-L1 and CD8A) and TMIT III (high PD-L1 and low CD8A) might represent non-inflamed tumors, while TMIT IV (low PD-L1 and high CD8A) stands for tumors with immune excluded microenvironment 71, 72. Here, CD8A is linked to neoplasm.