GSTM1 and neoplasm: To address the limitations of high dose-dependent tissue toxicity, non-selectivity, and radio-resistance, Dai and colleagues designed a facile X-ray nano-processor (Hb@Hf-Ce6 NPs) based on metal-phenolic self-assembly coordination for sufficient oxygen delivery in vivo and X-ray-triggered ultrasensitive ROS generation in the tumor microenvironment (TME) (Figure 18A) 79.