To determine whether ErbB2 degradation triggered by DEPTOR knockdown plays a causal role in the inhibition of cell proliferation and survival, we ectopically expressed ErbB2-YVMA, a constitutively active ErbB2 A775-G776insYVMA mutant from human tumor patients 23, in DEPTOR-depleted cells. This evidence concerns the gene DEPTOR and neoplasm.