ABCB1 and cancer: Furthermore, Wang et al. designed a biomimetic lipid/DEX hybrid nanogel to co-deliver MDR1 siRNA and PTX for inhibiting PTX-resistant ovarian cancer (Figure 7C) 115, in which MDR1 siRNA could knock down MDR1 to promote the accumulation of PTX in cancer cells, thereby achieving an efficient inhibitory effect against highly PTX-resistant cancer cells.