For example, the full-length mAb 376.96, which recognizes an epitope of B7-H3 that is expressed on ovarian cancer and cancer initiating cells, has been labeled with 212Pb for targeted α-particle therapy in intraperitoneal (i.p.)models of human ovarian cancer xenograft models, ES-2 and A2780cp20. The gene discussed is CD276; the disease is ovarian carcinoma.