Similarly, to detect AG PCa from low risk PCa and non-PCa at the same 95.0% sensitivity, the specificity for the four-marker panel of phi, Fuc-PSA, SDC1, and Tie-2, and the same phi, Fuc-PSA combinations had a specificity of 78.2% and 69.1%, respectively vs 65.5% for phi (p=0.010, and 0.207, respectively) and 36.4% for PSA alone. This evidence concerns the gene SDC1 and posterior cortical atrophy.