The best biomarkers to separate AG from low risk PCa were phi (AUC=0.872), PSA (0.866), Fuc-PSA (0.848), %fPSA (0.714]), GDF-15 (0.651), SDC1 (0.637), Tie-2 (0.635), and VCAM-1 (0.626), and to separate AG from low risk PCa and non-PCa were phi (AUC=0.898), PSA (0.807), Fuc-PSA (0.757), %fPSA (0.691), GDF-15 (0.673), B7-H3 (0.630), Tie-2 (0.620), and SDC1 (0.593). Here, CD276 is linked to posterior cortical atrophy.