Furthermore, two four-marker panels of phi, Fuc-PSA, SDC1, and GDF-15 or phi, Fuc-PSA, SDC1, and Tie-2 were identified with an even greater improved performance over phi individually to separate AG from either low risk PCa or low risk PCa and non-PCa with statistical significance. The gene discussed is KLK3; the disease is posterior cortical atrophy.