Similarly, a previous study showed that the C-terminal extracellular Ca2+ module of SPARC, a domain implicated in binding to endothelial cells 69 and to vascular cell adhesion molecule 1 (VCAM1) 70, is needed to enhance endothelial transmigration of melanoma cells via VCAM1 signaling 26. The gene discussed is SPARC; the disease is melanoma.