Increased TUNEL staining was also observed in acute ocular hypertension model, in both WT and Cav-1-/- mice groups although Cav-1-/- retinas displayed less increase in TUNEL positive cells in GCL in glaucoma (*p < 0.05; one-way ANOVA; Bonferroni post-hoc test; n = 8) (Figure 10 F, G) when compared to the WT retinas (***p < 0.001; one-way ANOVA; Bonferroni post-hoc test; n = 8) (Figure 10 E, G). Here, CAV1 is linked to ocular hypertension.