CTLA4 and neoplasm: In an initial study we tested cumulative doses of 2.5 Gy (20 μCi) and 12 Gy (100 μCi) of 90Y-NM600 in combination with anti-CTLA-4 and found that a cumulative dose of 12 Gy of 90Y-NM600 was more effective in reducing tumor growth and extending survival compared to 2.5 Gy (Figure S6).