Then the expression profiles of the six hub IAGs between tumor and normal tissue were presented in Figure S3, which displayed that GDF15, TUBB3 and SSTR1 were significantly upregulated in prostate cancer, while NFATC3 and IL1R1 were significantly downregulated when compared with normal tissue (p < 0.05). This evidence concerns the gene GDF15 and Familial prostate cancer.