Curcumin plays a significant role in the downregulation of the WNT/β-catenin pathway to prevent cancer and tumor growth, as it has been shown to promote apoptosis and inhibit tumor cell migration in hepatocellular carcinoma cells by decreasing expression of glypican-3, which can inhibit c-myc, cyclin D1, VEGF, and β-catenin expression, which in turn inhibited WNT/β-catenin signaling 110-113. The gene discussed is GPC3; the disease is neoplasm.