TWIST1 and neoplasm: The activation of PI3K/Akt signaling pathway could promote the mesenchymal transformation of malignant tumor epithelial cells by upregulating the level of phosphorylation Twist which was a key transcription factor in the EMT process 41-43, inhibiting the degradation of Snail by promoting the ubiquitination of GSK-3β 44, and directly upregulating Snail's endogenous expression in tumor cells 45.