AKT1 and carcinoma of esophagus: Our results showed that after CAR treatment, the protein expression of PI3K and AKT was downregulated in a dose-dependent manner; when oesophageal cancer cells were co-treated with the PI3K agonist 740Y-P and CAR, the inhibition of cell proliferation, invasion, migration, and EMT and the promotion of cell apoptosis by CAR were reversed.