It is pointed out that ANXA2 overexpression in NSCLC 59, HCC 105, serous ovarian cancer 106, biopsies of epithelial ovarian cancer 107, urothelial carcinoma 108, breast cancer 109, 110 and nasopharyngeal carcinoma (NPC) 84 was associated with poor prognosis. The gene discussed is ANXA2; the disease is hepatocellular carcinoma.