In addition to the above-mentioned genes, other genes play some roles in the progression and prognosis of tumors, such as CELSR3 in hepatocellular carcinoma 47, CCDC144NL in gastric cancer 48, RPE65 in nonmelanocytic skin tumor 49, SLC27A4 in lung cancer 50, MEX3A in bladder urothelial carcinoma 51, CAPN12 in laryngeal cancer 52 and SLC4A4 in breast cancer 53. The gene discussed is RPE65; the disease is bladder transitional cell carcinoma.