YTHDF1 and colorectal cancer: With respect to 'readers', both YTHDF1 and YTHDC1 were linked to higher GS, pathological T and pathological N. YTHDF1 is overexpressed in the colorectal cancer (CRC), and inhibition of Wnt/β-catenin pathway can be achieved by YTHDF1 silencing in CRC cells40.