Further, a total of 363 DE genes were identified between two clusters, and 11 eligible DE genes (CELSR3, CCDC144NL, SLC9A3, KLK14, PCOTH, RPE65, SLC7A4, TEX19, MEX3A, CAPN12 and RBFOX3) were eventually selected to establish the gene signature that could stratify PCa patients into different risk categories. Here, CELSR3 is linked to posterior cortical atrophy.