TEPP-46 and DASA-58, which are PKM2 activators, can bind PKM2 through a binding pocket distinct from that of fructose-1,6-bisphosphatase (FBP) and that they stabilize a tetrameric conformational state, which may impair cancer cell proliferation by interfering with anabolic metabolism 15. The gene discussed is FBP1; the disease is cancer.