It has been reported that SOX4 is upregulated in various malignancies, including HCC, pancreatic cancer, bladder carcinoma, prostate cancer, breast cancer, colorectal cancer, gastric cancer and melanoma 11, 12, 14, 32, 40-44, raising the potential of this gene as a diagnostic marker. The gene discussed is SOX4; the disease is familial pancreatic carcinoma.