For Homer3, its expression in HCC was lower than that in cirrhosis (P < 0.01), hepatitis B (P < 0.01) and the controls (P < 0.01) and Homer3 expression in cirrhosis (P < 0.05) and hepatitis B (P < 0.01) were lower than that in controls. Here, HOMER3 is linked to hepatocellular carcinoma.