The decrease of downstream gluconeogenesis enzymes, such as phosphoenolpyruvate carboxykinase1 (PCK1) and fructose-1,6-bisphosphatase 1 (FBP1) expression, in HCC lead to the suppression of gluconeogenesis and elevation of glycolysis 30, 31. The gene discussed is FBP1; the disease is hepatocellular carcinoma.