DCR was associated with AFP > 400 ng/ml (OR 0.57, 95% CI 0.36–0.9), European sites (OR 3.97, 95% CI 1.91–8.24), and chronic hepatitis C (OR 2.04, 95% CI 1.14–3.66) in univariable analysis. The gene discussed is AFP; the disease is chronic hepatitis C virus infection.