MSLN and cancer: These shared antigens can be separated into three main groups: the overexpressed antigens, which are normal surface proteins expressed in elevated levels on cancer cells, but in lower levels in normal cells (e.g. hTERT, HER2, mesothelin, and MUC-1); tissue-specific TAAs, which are shared between tumors and the normal tissue of their origin [e.g. tyrosinase, gp100, MART-1, prostate-specific antigen (PSA)]; and TAAs whose expression is normally restricted to male germline cells [i.e. cancer testis (CT) antigens, such as MAGE-A1, MAGE-A3, and NY-ESO-1].71