Based on the network analysis, we found seven key bioactive compounds (quercetin, <i>ß</i>-sitosterol, luteolin, kaempferol, supraene, curcumenolactone C, and stigmasterol) of DNt might treat NAFLD via intervening IL6, MAPK8, VEGFA, CASP3, ALB, APP, MYC, PPARG, and RELA. This evidence concerns the gene APP and metabolic dysfunction-associated steatotic liver disease.