Previous work in a cohort of 135 GBMs detected PD-L1 gene expression and Tumour Infiltrating Lymphocytes (TILs) in the majority of GBM cases suggesting potential utility of ICIs, although PD-L1 expression and TILs density were shown to be unrelated to GBM outcome and methylation status was not well defined [12]. This evidence concerns the gene CD274 and neoplasm.