In addition, we observed higher overall mean normalised values of the checkpoint molecule B7-H3 (CD276) irrespective of methylation status; MGMT methylated (tumour core: 14.07 [1.02], MGMT methylated tumour margin: 12.70 [0.94]) compared to MGMT unmethylated GBM (tumour core: 12.35 [0.87], tumour margin: 12.52 [1.44]). This evidence concerns the gene CD276 and neoplasm.