Additionally, in a study by Fecci et al., it has been shown that absolute counts of both CD4+ T-cells and CD4+ CD25+ FOXP3+ CD45RO + T-cells (i.e., Tregs) are reduced in patients with malignant glioma, yet there is an increased fraction of the CD4+ compartment [27]. This evidence concerns the gene FOXP3 and malignant glioma.