XIST and central nervous system cancer: Yu et al. (2017) found that XIST is upregulated in endothelial cells in a blood–tumor–barrier model in vitro. FOXC is a transcription factor of the forkhead box family, and it promotes glioma angiogenesis by activating the expression of CXCR7 [chemokine (C–X–C motif) receptor 7b] (Yu et al., 2017).